Chronic silent inflammation

Ω Krill oil is active and healthy under many conditions and can influence many diseases. The reason for this wide impact range is that many diseases are linked to a process called chronic silent inflammation.
Normally inflammation helps to activate all forces to fight an acute attack in the body.

An acuted inflammation Is started when pro-inflammatory hormones (cytokines and prostagladins) send signals to the white blood cells to clear out indruders (antigens), damaged tissue and infected areas of the body.

The inflammatory process will neutralize and eliminate the antigens and begin the healing process. Usually inflammation is working efficiently only in an acute state and is well adapted and reduced according to specific needs.
However,sometimes the inflammatory response does not shut down when the danger is over and the inflammation becomes chronic.

Stress, smoking, obesity and high blood sugar levels,but also bacteria,viruses and parasites can all contribute,whereas some persons are genetically predisposed towards inflammation.
Diet, exposure to toxins,germs, pollutants and inhalants might further influence a person to develop an overactive immune system.

Diseases which are linked to inflammation:

Atherosclerosis
Heart Diseases
High Blood Pressure
Diabetes
Obesity
Allergies
Asthma
Alzheimer
Parkinson
Rheumatoid Arthritis
Inflammatory Bowel Diseases
Colitis Ulcerosa
Morbus Crohn
Cancer
Psoriasis

Specific foods containing omega -6 fatty acids promote inflammation. Omega-6 fatty acids are converted in our body into more pro-inflammatory molecules than are omega-3 fatty acids.
To reduce the likelihood of the diet contributing to an out of control inflammatory system,it is advised to eat plenty of fish and vegetables and in particular high risk persons should consider supplementation with an omega-3 fatty acid product.
Irrespective of the diet, an inflammatory response can also be promoted by being overweight.
Fat cells produce immunomodulating factors (cytokines), which can lead to an inflammatory response in the body.
Moreover, age is related to increases in systematic signs of inflammation and isomnia can worsen an inflammatory response. Sufficient sleep is important for the immune system to subside and slow down cytokine secretion.

Inflammation has been recognized as being of importance in the development and progression of atherosclerosis. Coronary inflammation can lead to plaque rupture and blood clot formation in the heart.
Several inflammatory markers can indicate the presence of chronic inflammation and risk for cardiovascular disease, i.e. fibrinogen, C-reactive protein (CRP) and interleukin-6.
Fibrinogen, a protein important for blood coagulation,can raise the risk for a heart attack through increased platelet aggregation and excessive blood thickening.
One study showed that people who have high levels of fibrinogen are twice as likely to suffer from heart attack as those with normal levels.

The inflammatory response also stimulates production of another marker, called CRP.
CRP is produced by the liver. It is not a contributor to heart disease, but it is an indicator for inflammation that is associated with atherosclerosis. Individuals with increased CRP levels have shown to be three times as likely to have a heart attack as those with normal levels.

CRP production in the body is induced by the inflammatory cytokine.
IL-6 that stimulates immune responses.
A recent study showed that IL-6 can increase the risk of heart attack, even after adjustment for CPR elevation.

The best protection against coronary artery complications induced by inflammatory markers is to endeavor to reduce the levels of fibrinogen, CPR and IL-6 in the body naturally.

In a human study, krill oil showed benefits in fighting chronic inflammation and arthritic symptoms. The clinical trial involved 90 male and female patients with cardiovascular disease and/or rheumatoid arthritis and/or osteoarthritis.They received 300mg krill oil daily for 30 days. Already, after seven days of treatment, krill oil reduced the pro-inflammatory cytokine CRP by 19,3% compared to a dicrease of 15,7% in the control group. After 14 days of krill oil suplemmenation the CRP levels were further decreased by a total of 29,7% , whereas in the placebo group the CRP levels increased again.

Krill oil treatment significantly reduced pain (-28,9% ), stiffness (-20,3% ) and functional impairment (-22,8% ), when compared to placebo already after seven days of treatment. Therefore any reduction in CRP by krill oil could be beneficial in the treatment/prevention of inflammatory related diseases.

Studies have shown that krill oil is also beneficial for people suffering from allergies, since it can reduce acute inflammation and rebalance the immune response.
Specifically, the over accumulation of immune factors, called eosinophilis, has been linked to the development of allergic disorders.

Asthma is a major public health problem which medicidine tries to control by treating bronchial inflammation.Most asthmatics suffer from mild forms of the disease and non-pharmacologic interventions are therefore attractive.The anti-inflammatory potential of krill oil make it interesting also for the treatment of bronchial infammation,and house dust allergies.

In a study lasting 5 weeks, 23 house dust mite-allergic asthmatics were given krill oil at a dose of 690mg/day or placebo. After 3 weeks,the asthmatics were challenged with a daily low dose of mite allergen for the remaining 2 weeks. The study outcome suggests that dietary supplementation with krill oil is able to decrease bronchial inflammation even after exposure to the allergen.

Inflammation in the tumor microenviroment is now recognized as one of the risk factors for Breast cancer, Cachexia, Cancer (general), Cervial cancer, Colon cancer, Lung cancer, Prostate cancer.

Endogenously produced metabolites from lipids can act as mediators and play a central role in inflammation and tissue homeostasis.
Reducing inflammation and the overall risk of the development of cancer by increasing the consumption of marine omega-3 fatty acids and reducing the intake of pro-inflammatory omega-6 fatty acids can help in cancer prevention and treatment. And this is an evidence for an emerging role of omega-3 fatty acids in cancer therapy for e.g. breast cancer, colon cancer metastasis, liver cancer and generalized malignancy.
Ω krill oil appears to possess some anti-cancer properties. A study looking at the exposure of human cancer cells to different concentrations of krill oil for 48 hours found that cancer cell growth was inhibited in a dose dependent manner. Krill oil was also shown to inhibit cancer cells in a time dependent manner with more pronounced inhibition occurring at 72 hours and 120 hours after treatment.